日达仙治疗慢性重型肝炎临床观察

Observation of Thymosin-α_1 in the Treatment of Chronic Severe Hepatitis

目的 :探讨日达仙治疗慢性重型肝炎的疗效。方法 :6 2例慢性重型肝炎在综合保肝对症治疗基础上 ,治疗组 32例加用日达仙治疗 ,分别观察治疗前后症状、体征、肝功能、感染情况、病死率。结果 :临床症状乏力、纳差、腹胀、出血的改善 ,肝功能、凝血酶原活动度的好转、降低感染及病死率方面治疗组均优于对照组 ,两组比较P <0 0 5 ,差异有显著性 ,治疗组无不良反应。结论 :日达仙能显著减轻肝细胞损伤程度 ,降低病死率 ,且患者耐受性好 ,无不良反应。

Objective:To observe the effectiveness of thymosin-α 1 in treating chronic severe hepatitis.Methods:Sixty-two patients with chronic severe hepatitis were treated with synthetic methods,32 patients in treatment group were also given thymosin-α 1 at the same time.We observed the symptoms,signs,alanine aminotransferase,total bilirubin,prothrombin time,infection,and mortality before and after the treatment.Results:The treatment group was significantly better than the control group.There was a significant difference (P<0.05) and no adverse reaction was observed.Conculsion:Thymosin-α 1 can reduce the injury of the hepatocythe, decrease the mortality,and has no adverse reaction.