尿α1-微球蛋白对术后早期移植肾功能监测的研究

Significance of urine α1-microglobulin in monitoring implants function during early stage of kidney transplantation

目的 尽早发现移植肾功能损害 ,及时处理以提高肾移植成功率。方法 对 5 6例尸体肾移植患者早期进行尿α1-微球蛋白测定 ,依据术后住院期间肾功能恢复情况进行分组 ,并与健康人做比较。结果 急性排斥组较肾功能稳定组α1-微球蛋白高 4倍 (P<0 .0 5 ) ;较健康组高 2 0倍 (P<0 .0 1)。结论 在移植肾功能损害尤其是急性排斥反应时 ,尿α1-微球蛋白能及早反映其存在并指导及时处理。

Objective To advance the success rate of kidney transplantation by finding the damage of transplanted kidney at early stage and treating it promptly.Methods The α1-microglobulin levels in urine were determined 56 patients having undergoing kidney transplantation and compared with serum creatinine levels.Results The urine α1-microglobulin concentration in acute rejection group was 4 times higher than that in the stable kidney function group.Conclusion α1-microglobulin is a sensitive and promising parameter in reflecting the function of kidney.