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转移抑制基因nm23的研究进展

Recent Advances in nm 23 Genes
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摘要 nm2 3是发现的第一个肿瘤转移抑制基因。目前已发现了 9个nm2 3基因家族的成员 ,它们可分为两组。其编码的蛋白具有多种生物化学功能 ,有些功能可能与它抑制肿瘤转移的作用有关。这些蛋白除了是酶外 ,还与众多蛋白间有交互作用并可参与其他基因的转录。 The first metastasis suppressor gene identified was nm23. Nine human nm 23/NDP kinase-homologous proteins have been identified and they fall into two categories. nm23 proteins possess multiple biochemical functions. To date, researches have revealed that several properties of nm23/NDP could modulate metastasis of cancer cells. Besides serving as enzymes, these proteins have been reported to interact with several protein partners and to activate or repress the transcription of genes.
作者 党雅梅 李敏 王金穗
机构地区 甘肃省人民医院
出处 《医学分子生物学杂志》 CAS CSCD 2004年第6期373-375,共3页 Journal of Medical Molecular Biology
关键词 NM23基因 肿瘤转移抑制基因 蛋白 研究进展 抑制肿瘤 发现 家族 转录 生物化学 交互作用 nm23 genes advances protein-protein interaction
分类号 R737 [医药卫生—肿瘤] R735 [医药卫生—肿瘤]
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参考文献14

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  • 3Wei SJ, Trempus CS, Ali RC, et al. 12-O-Tetradecanoy-Lphorbol-13-acetate and UV Radiation induced Nucleoside Diphosphate Protein Kinase B Mediates Neoplastic Transformation of Epidermal Cells. J Biol Chem,2004;279(7): 5 993-6 004.
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医学分子生物学杂志
2004年 第6期

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