摘要
目的 探讨半乳糖凝集素Galectin 3(G 3)在脑星形胶质细胞瘤中的表达。以及与星形胶质细胞瘤WHO分级之间的关系。方法 应用免疫组化SP法检测 6 0例脑星形胶质细胞瘤标本中Galectin 3的表达 ,并检测不同的分级之间是否具有差异性。结果 Galectin 3的阳性率为 85 % ,随着肿瘤恶性程度增加 ,阳性细胞数目增加 ,不同WHO分级之间阳性表达率差异具有显著性。结论 Galectin 3在星形胶质细胞瘤中的阳性表达率与WHO分级有关 ,并可作为星形胶质细胞瘤恶性程度的重要分级指标。
Objective To investigate the lection of galectin 3 in human astrocytoma and the relationship between the level of expression and the grade of WHO.Methods Expression of galectin 3 was examined in 60 specimens of astrocytoma with immunohistochemical technique. Results The rate of the expression in astrocytoma was 85% .The positive galectin 3 immunostaining significantly increased with the degree of malignancy increase.There was significant difference in different WHO grade.Conclusions There is a retatinship between the expression level and WHO grade.Galectine 3 is an important index in classification of degree of malignancy.
出处
《卒中与神经疾病》
2004年第6期381-384,共4页
Stroke and Nervous Diseases
