P57^(kip2)蛋白在进展期胃癌中的表达及临床意义

Expression and clinical significance of P57^(kip2) protein in advanced gastric carcinoma

目的 探讨P5 7kip2 (P5 7)蛋白在进展期胃癌中的表达及临床意义。方法 采用免疫组化S P法检测 30例进展期胃癌标本和对照组 10例胃正常黏膜组织标本中P5 7蛋白的表达。结果 在进展期胃癌标本中P5 7蛋白的阳性表达率为 36 .7% (11 30 ) ,对照组中P5 7蛋白阳性表达率为 90 .0 % (9 10 ) ,组间差别显著 (P <0 .0 5 )。在高 中分化的胃癌组P5 7蛋白的阳性表达率 6 3.3% (7 11) ,在低分化的胃癌组P5 7蛋白的阳性表达率为 2 1.2 % (4 19) ,组间比较有显著差异 (P <0 .0 5 )。结论 P5 7可能与胃癌的发生有关 ,并可作为判定胃癌恶性程度的重要生物学指标。

Objective To study the expression and clinical significance of P57 kip2 (P57) protein in the tissue of advanced gastric carcinoma.Methods Immunohisto-chemical studies for the expression of P57 protein in 30 specimens of advanced gastric carcinoma and 10 specimens of normal gastric tissue which was used for control group.Results The total expression rate of P57 was 36.7%(11/30) in advanced gastric carcinoma,which was significantly lower than that in the control group.P57 was less expressed in poorly-differentiated gastric carcinoma than in highly and moderately-differentiated gastric carcinoma (21.2% vs 63.3%,P<0.05).Conclusion P57 might play an important role in the carcinogenesis of gastric carcinoma.It might serve as an indicator of malignancy degree of gastric carcinoma.