粒细胞-巨噬细胞集落刺激因子在呼吸道感染患儿血清中的变化

Changes in serum level of GM-CSF in children with respiratory tract infection

目的 :检测粒细胞 巨噬细胞集落刺激因子 (GM CSF)在呼吸道感染患儿血清中的变化 ,为临床诊断细菌性呼吸道感染提供可靠依据。方法 :采用放射免疫法检测 61例呼吸道感染患儿 (观察组 )血清GM CSF水平以及血清中C反应蛋白 (CRP)和外周血白细胞、中性粒细胞计数的变化 ,并与 2 2例正常儿童 (对照组 )进行比较。结果 :①观察组GM CSF平均值高于对照组 ,存在显著差异 (P<0 0 5 ) ;②观察组 60例检测CRP ,阳性 8例 ,与GM CSF相比 ,两者存在显著差异 (P <0 0 5 ) ;③观察组GM CSF与白细胞、中性粒细胞计数比较 ,存在正相关 (P <0 0 1)。结论 :GM CSF是反应细菌感染的重要指标 。

Objective:To investigate the changes in serum granulocyte-macrophage colony stimulating factor (GM-CSF) in children with respiratory tract infection and to provide a reliable basis for clinical diagnosis of bacterial respiratory tract infection.Methods:Radioimmunoassay (RIA) was applied to detecting serum levels of GM-CSF,C-reactive protein (CRP),leucocyte count and neutrophil cell count in 61 children with respiratory tract infection (study group),and in 22 healthy children (controls).Results:① In the study group,the mean serum level of GM-CST was higher than that in controls with a significant difference (P<0.05).② In the study group,CRP was dectected positively in 8 cases.Its positve rate was significantly different from that of GM-CSF (P<0.05).③ Within the study group,serum GM-CSF level was positively correlated with WBC count and neutrophil cell count (P<0.01).Conclusions:Serum GM-CSF was an important indicator of bacterial infection and was significant to rational use of antibiotics.