泌尿系统感染的病原菌分布及耐药性分析

Distribution and Drug Resistance of Pathogens in Urinary System Infection

目的探讨泌尿系统感染的病原菌分布及其耐药特征,为临床合理选用抗生素、控制医院内尿路感染提供依据。方法分离129株尿培养阳性的病原菌进行鉴定及药敏,同时对G-杆菌进行ESBLs的检测,对葡萄球菌属做甲氧西林耐药检测,肠球菌属细菌进行氨基糖苷类高水平耐药(HLAR)的筛选。结果病原菌分布为大肠埃希菌5116%、金黄色葡萄球菌1085%、凝固酶阴性葡萄球菌775%、肠球菌属占620%及假单胞菌属占543%;产ESBLs的大肠埃希菌、肺炎克雷伯菌的检出率分别为2576%、4000%,耐甲氧西林金黄色葡萄球菌(MRSA)、凝固酶阴性葡萄球菌(MRCONS)的检出率分别为5714%、5000%,高水平耐氨基糖苷类(HLAR)肠球菌检出率为5000%。结论重视尿路感染病原菌及其耐药性检测,对控制医院内尿路感染、合理使用抗生素十分重要。

OBJECTIVE To study the distribution and drug resistance characteristic of pathogens in urinary system infection,and to provide basis for clinicians to select antibiotics correctly and to control nosocomial urinary infection. METHODS A total of 129 pathogen strains were identified, which were isolated from urine of our hospital patients with urinary system infection. ESBLs producing G - bacteria, and oxacillin resistance in staphylococci were detected and high level aminoglycoside resistance in enterococcus(HLAR) were screened. RESULTS Among 129 strains, 51 16% were Escherichia coli, 10 85% Staphylococcus aureus, 7 75% coagulase negative Staphylococcus(CONS), 6 20% Enterococcus and 5 43% Pseudomonas were detected respectively. 25 76% E.coli and 40 00% Klebsiella pneumoniae produced ESBLs; 57 14% S.aureus and 50 00% CONS were resisted to oxacillin; HLAR producing Enterococcus was 50 00%. CONCLUSIONS Much attention should be paid to do detection and drug resistance of pathogens in urinary system infection. It is important to control nosocomial urinary infection and select antibiotics correctly.