摘要
目的:研究胆碱中枢镇痛效应的药效学特征.方法:通过小鼠热板实验观察不同剂量胆碱的镇痛作用及多种拮抗剂对其镇痛作用的影响,探讨胆碱镇痛作用的可能途径.结果:胆碱(90～120μg/只)可以产生镇痛作用,且能被MLA(50 μg/只)、α-银环蛇毒素(2μg/只)和阿托品(0.1μg/只)所拮抗,但不能被美加明(5μg/只)和纳洛酮(2μg/只)所拮抗.结论:胆碱镇痛作用可能通过α7烟碱受体亚型介导,且可能与M受体有关.
AIM: To investigate the characteristics of the antinociceptive effects of choline in central nervous system (CNS) in mice. METHODS: Hot-plate test (icv) was used to study the antinociceptive effects of choline, the influences of many antagonists on the antinociceptive effects of choline were observed, the potential mechanisms underlying the antinociceptive effects of choline were discussed. RESULTS: With the administration of choline 90 - 120 μg per mouse, antinociceptive effects showed in a dose-dependent manner. MLA(50μg permouse), α-BTX(2 μg per mouse) and atropine(0.1 μg per mouse) significantly blocked the effect of choline; mecamylamine(5μg per mouse) and naloxone(2μg per mouse) failed to block choline-induced antinociception. CONCLUTION: Choline-induced antinociception is mediated by α7-nAchR subtype, while mAchR seems to be related to choline-induced antinociception.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第11期1217-1220,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金资助项目(№30371641)北京赛德维康医药研究院新药研究基金项目资助(№1999001)
