血清铜含量变化在原发性骨质疏松症危险因素中的作用

Role of changes of serum copper level in the risk factors of primary osteoporosis

目的:探讨血清铜与原发性骨质疏松症的关系,为防治原发性骨质疏松症提供理论依据。方法:从1997-09/1998-06来福建中医学院附属第二人民医院的健康体检者中,收集到完整标本者170例。双能X射线骨密度仪测定L1～4骨密度;全自动生化分析法测定尿钙、肌酐;AKP用比色法,Ca,Mg用MTB法,P用磷酸亚铁胺法,Cu用双环己酮草酰二腙比色法。获得的参数骨质疏松组与正常对照组比较。结果:原发性骨质疏松组骨代谢生化指标与同年龄的对照组比较,血清Ca,P,Mg两组差异无显著性意义;尿钙与肌酐比值非常明显地增多;血清Cu(μmol/L)骨质疏松组(189.8±38.5)显著低于对照组(204.0±35.5);然而,按性别分别处理时,男女骨质疏松组与其对照组相比,血清Cu水平虽有降低犤其中男性骨质疏松组与对照组的值分别为(181.8±36.5),(191.7±19.5)μmol/L;女性骨质疏松组与对照组的值分别为(197.0±37.1),(209.4±39.7)μmol/L犦,但差异无显著性意义。结论:原发性骨质疏松症的发病因素是多方面的,血清铜水平的降低是原发性骨质疏松症的发病因素之一,但其重要性有待进一步研究。

AIM:To study the relationship between level of serum copper(Cu) and primary osteoporosis so as to provide a theoretical evidence for preventing and treating primary osteoporosis.<METHODS:From September 1997 to June 1998,170 intact specimens of hematuria were collected during health examination in the Second Affiliated People's Hospital of Fuanjian Medical College.Spinal bone(L1- 4) mineral density was measured by dual energy X ray absorptiometry;urine calcium(Ca) and creatinine were measured with a fully automatic biochemical analyzer;serum AKP with colorimetric method,serum Ca and magnesium(Mg) with MTB method,serum phosphorus(P) with ferrous phosphate amine method;and serum Cu with biscyclohexanone oxalyldihydrazone photometric method.The obtained parameters were compared between osteoporosis and control groups.<RESULTS:The biochemical indexes of bone metabolism in terms of serum Ca,P and Mg were not significantly different between primary osteoporosis and normal control group in the same ages.The ratio of urine Ca to creatinine was significantly increased in the primary osteoporosis group,as compared with that in the control group,while the level of serum Cu in the former group[(189.8± 38.5) μ mol/L] was significantly lower than that in the latter group[(204.0± 35.5) μ mol/L].The level of serum Cu was insignificantly different when comparing male and female in primary osteoporosis groups with their controls respectively,though it was a little decreased[(181.8± 36.5) and (191.7± 19.5) μ mol/L in male primary osteoporosis group and its control group respectively,(197.0± 37.1) and (209.4± 39.7) μ mol/L in female primary osteoporosis group and its control group respectively] without significant difference.<CONCLUSION:The etiological factors of primary osteoporosis are various,and the decrease of serum Cu level is one of them,but its importance needs further research.