定量超声技术对早期婴儿骨状况的评估作用

Evaluation on the status of bone in early infants detected with quantitative ultrasound

目的:应用定量超声(quantitativeultrasound,QUS)技术研究早期婴儿骨状况,探讨早期婴儿骨发育中的一些现象。方法:采用以色列Sunlight公司生产的Omnisense定量超声仪,对542例0～3个月内婴儿进行胫骨声波速度(speedofsound,SOS)测量。结果:①0～3个月婴儿男(327例)女(215例)间SOS值差异无显著性意义(F=0.963,P=0.327)。②早产儿在校正胎龄(correctedgesta-tionalage,CGA)达到39～42周时与相同胎龄足月儿相比,其SOS值显著性低于足月儿。③婴儿SOS值与生后年龄呈负相关(早产儿:r=-0.356,n=139,P=0.001;足月儿:r=-0.265,n=403,P=0.001)。④婴儿出生后SOS值有下降趋势,早产儿SOS值下降较足月儿明显,胎龄越小,SOS值下降越明显。结论:早期婴儿有SOS值下降的现象,早产儿SOS值低于足月儿,应该加强对早产儿骨状况的关注和早期干预。

AIM:To study the status of bone with quantitative ultrasound(QUS) in early infants,and explore the phenomena of bone development to direct the clinical rehabilitation of children.<METHODS:An Omnisense ultrasound bone sonometer,produced by the Sunlight Company of Israel,was applied to measure the tibial speed of sound(SOS) in 542 infants of 0 to 3 months old.<RESULTS:① No significant difference of SOS was found between the male(n=327) and female(n=215) infants of 0 to 3 months old(F=0.963,P=0.327).② The SOS of premature infants was significantly lower than that of full term infants when the corrected gestational age(CGA) of the premature infants reached 39 to 42 weeks.③ The SOS of the infants had negative correlation with the chronological age after birth(premature infants:r=- 0.356,n=139,P=0.001;full term infants:r=- 0.265,n=403,P=0.001).④ There was decrease of bone SOS with the increase of age in the infants,and it was more obvious in the premature infants than in full term infants.The smaller the gestational age,the more markedly the bone SOS decreased.<CONCLUSION:Bone SOS has the trend of decrease in early infants,bone SOS of the premature infants is lower than that of the full term infants,so the particular care and early intervention for the bone status of premature infants should be reinforced.