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结缔组织生长因子与肺纤维化及呼吸功能 被引量：2

Relationship of connective tissue growth factor with pulmonary fibrosis and respiratory function
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摘要 目的:了解结缔组织生长因子(connectivetissuegrowthfactor,CTGF)在肺纤维化发生、发展中的作用。资料来源:应用计算机检索Medline1991-06/2002-10关于生长因子、肺纤维化和呼吸功能的相关文章,检索词“connectivetissuegrowthfactor,transforminggrowthfactor,pulmonaryfibrosis,并限定文章语言种类为English。同时计算机检索《中国临床康复》杂志2003-01/2004-08期间的相关文章,限定文章语言种类为中文,检索词“结缔组织长因子,转化生长因子,肺纤维化”。资料选择:对检索到的CTGF,转化生长因子及肺纤维化研究文章中的相关信息进行综述,纳入标准为①随机对照的基础及临床试验(RCT)。②无论是否为单盲,双盲或非盲法。资料提炼:共检索到相关文章43篇,对检索到的CTGF,转化生长因子及肺纤维化相关35篇文章中的相关信息进行综述,8篇综述性文章不符合纳入标准予以排除。资料综合:实验研究提示,CTGF是一种富含半胱氨酸的分泌性多肽,有促进细胞增殖,加速DNA合成;促进血管形成;促进成纤维细胞的增殖、刺激细胞外基质的合成;介导细胞黏附,刺激细胞迁移;诱导细胞凋亡的生物学活性。与皮肤、肝、肾、肺等组织器官纤维化及增生性疾病有着重要联系。CTGF基因属于早期即刻反应基因,启动子含TGF-β应答元件,可被TGF-β?
作者 全燕 夏前明
机构地区 解放军成都军区总医院呼吸科
出处 《中国临床康复》 CSCD 2004年第36期8376-8378,共3页 Chinese Journal of Clinical Rehabilitation
关键词 结缔组织 生长物质 肺纤维化 转化生长因子Β
分类号 R56 [医药卫生—呼吸系统]
  • 相关文献

参考文献24

  • 1[1]Bork P. The modular architecture of a new family of growth regulators related to. FEBS Lett 1993;327(2): 125 - 30
  • 2[2]Bradham DM, Igarashi A, Potter R, et al. Connective tissue growth factor: a cydteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 1991; 114(6):1285 - 94
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二级参考文献21

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共引文献17

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二级引证文献16

中国临床康复
2004年 第36期

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