不同部位气单胞菌感染的特点、药物敏感性及预后

Features,drug sensitivity and prognosis of infection by aeromonas at different parts of body

目的分析比较不同部位气单胞菌感染的特点、药物敏感性及预后。方法搜集不同部位的气单胞菌感染病例及菌株,加以分析比较。结果气单胞菌感染的特点是血液中以嗜水气单胞菌为主,腹水及大便中以温和气单胞菌为多,血液及腹水感染的气单胞菌以院内感染为主,主要发生于重症肝炎及肝硬化患者,预后较差,而肠道气单胞菌均为院外感染,主要与不洁饮食有关。不同部位感染的气单胞菌对抗生素的耐药率比较略有不同,但无显著差异。敏感率较高的抗生素包括头孢吡肟、左旋氧氟沙星、头孢噻肟及头孢曲松。肠道气单胞菌感染治愈率达100%;而败血症及腹膜炎的病死率分别达28.6%及37.5%。结论不同部位气单胞菌感染的预后不同,患者的整体状况是影响患者预后的关键所在。

Objective To investigate the features,drug sensitivity and prognosis of infection by aeromonas at dif- ferent pans of hody.Methods The cases of aeromonas infection at different parts of the body were reviewed and stains of aeromonas isolated for analysis and comparison.Results The aeromonas hydrophila was mainly found in blood while aero- mons sobria in ascites and stool.The aeromonas infection in the blood and ascites was mainly caused by cross infection in the hospital.Meanwhile,it predominantly occurred in patients with severe hepatitis or liver cirrhosis and had worse prognosis. The aeromonas infection of the intestinal tract occurred outside of the hospital and as mainly due to unclean diet.The drug resistance was slightly different among aeromonas strains isolated at different parts of the body.The strains were highly sensi- tive to cefepime,cefotaxime,ceftriaxone and levofloxacin.The curative rate for aeromonas infection of the intestinal tract was as high as 100%.However,the mortality in the patients with sepsis or peritonitis caused by aeromonas was 28.6% and 37.5%,respectively.Conclusions The prognosis of aeromonas infection at different parts of the body is various.The sys- tematic condition of the patients is a crucial factor for prognosis of the infection.