亚临床肝性脑病患者的认知状况及其P300电位研究

A study on cognition and P300 potentials in the early subclinicalhepatic encephalopathy

目的:探讨P300电位在评价亚临床肝性脑病患者认知功能中的作用。方法:对38例亚临床脑病患者和36例健康者分别进行了P300电位测定和认知能力筛查实验(CASI)并将两组结果进行了比较。结果:亚临床肝性脑病患者的P300电位成分中N2和P3波潜伏期延长及P3波幅降低,与健康对照组存在显著性差异(P<0.01),CASI测定中9个因子分及总分患病组均低于健康对照组;两组差异存在显著性(P<0.01或P<0.05)。结论:P300电位能及早反映亚临床肝性脑病患者的认知状况,对其临床治疗有较高的价值。

Objective: To investigate the effect of P300 potentials on the appraisal of cognition in the subclinical hepatic encephalopathy. Methods: P300 potentials test and cognitive ability screening instrument (CASI) were used for thirty- eight subclinical hepatic encephalopathy and thirty- six healthy people, the results were compared in the two groups. Results: Latent periods of N2 and P3 of P300 potentials in subclinical hepatic encephalopathy were longer and the amplitude of P3 was lower than those in the controls, there was significant difference between the two groups (P<0.01). The nine factors and total score of CASI test in subclinical hepatic encephalopathy were significantly lower than those in the controls (P<0.01 or P<0.05). Conclusions: P300 potentials can refect the cognition of subclinial hepatic encephalopathy earlier, which has remarkable value in evaluating the effect of treatment for subclinial hepatic encephalopathy.