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高龄老人严重感染应用万古霉素治疗的安全性研究 被引量:7

STUDY OF SAFETY IN TREATMENT WITH VANCOCIN CP FOR OLDEST- OLD SUFFERED FROM SERIOUS INFECTION
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摘要 目的评价万古霉素(商品名)稳可信治疗高龄老人严重感染的安全性。方法应用回顾性调查方法对稳可信治疗的42例严重感染的高龄老人进行分析,资料用t检验分析。结果稳可信治疗有效率高达90.5%(38/42),无严重毒副作用,仅1例有GPT轻度升高,后自行下降。25例MRSA万古霉素敏感性达100%。结论稳可信对高龄老人严重感染治疗有效,在药物体内浓度及肝肾功能监测下应用,安全性高。 Objective To evaluate the safety of Vancocin Cp in treatment of serious infection in oldest- old people. Methods 42 cases with serious infection were retrospectively analyzed with t test. Results The clinical efficacy rate was 90.5% ( 38/42) , and incidence of adverse drug reaction was rare,only 1 case had the rise of GPT. Conclusions Vancocin Cp is safety and efficacy to treat serious infection in oldest- old people. [
机构地区 华东医院心内科
出处 《老年医学与保健》 CAS 2004年第4期237-239,共3页 Geriatrics & Health Care
关键词 高龄老人 万古霉素 安全性 Aged,80 and over Vancomycin Safety
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参考文献4

  • 1Foote EF, Dreitlein WB,Steward CA.Pharmacokinetics of vancomycin when administered during high flux hemodialysis.Clin Nephrol,1998,50(1): 51-55.
  • 2Barth RH,DeVincenzo N.Use of vancomycin in high- flux hemodialysis: experience with 130 courses of therapy.Kidney Int,1996,50(3): 929-936.
  • 3Cohen E, Dadashev A, Drucker M,et al.Once- daily versus twice- daily intravenous administration of vancomycin for infections in hospitalized patients.J Antimicrob Chemother,2002,49(1): 155-160.
  • 4Tanaka M,Orii T.Kobayashi H,et al.Examination of factors affecting efficacy and adverse effect, for the retrospective study of vancomycin hydrochloride(VCM).药学杂?,2001.121(8): 621-629.

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