摘要
目的对比米氮平与氟西汀治疗抑郁症的疗效和安全性。方法将47例抑郁症患者分为两组,分别给予米氮平、氟西汀治疗,其中米氮平组24例,剂量为(29.6±10.2)mg蛐d;氟西汀组23例,剂量为(34.4±8.3)mg蛐d,疗程共6周。采用汉密顿抑郁量表(HAMD)和副反应量表(TESS),在治疗前和治疗后第1、2、4、6周末分别评定疗效和副反应。结果(1)两组治疗后与治疗前HAMD评分比较,差别有非常显著性意义(P<0.01)。(2)两组从治疗第1周末起,各时点HAMD减分率差别有非常显著性意义(P<0.01)。(3)6周末,米氮平组和氟西汀组的有效率分别为91.7%和87.0%,疗效的差别无显著性意义(P>0.05)。(4)TESS评定显示,米氮平的常见副反应发生率低于氟西汀,但差别无显著性意义(P>0.05);米氮平组嗜睡和体重增加的发生率高于氟西汀组,差别有显著性意义(P<0.05)。结论米氮平治疗抑郁症疗效好、起效快、副反应较低。
Objective To compare the efficacy and safety of mirtazapine with fluoxetine in treatment of depression. Methods Forty seven patients with depression were divided into two groups, 24 patients were treated with mirtazapine ,29.6±10.2 mg,day, and 23 patients with fluoxetine ,34.4±8.3 mg,day, for 6 weeks respectively. Hamilton Depression Scale ,HAMD, and Treatment Emergent Symptoms Scale ,TESS, were used before treatment and 1, 2, 4, and 6 weeks after treatment to assess the therapeutic efficacy and side effects. Results ,1, The HAMD scores for both groups were significantly decreased after treatment ,P<0.01,. ,2, The decreasing rates of HAMD scores between two groups were significantly different ,P<0.01, at all time points from the end of first week, ,3, At the end of the 6th week, the efficacy rate of mirtazapine and fluoxetine was 91.7% and 87.0% respectively ,P>0.05,. ,4, TESS scores indicated that the occurrence of common side effects of mirtazapine was similar to fluoxetine ,P>0.05,, but the occurrence rate of drowsiness and weight gain in mirtazapine group was higher that that in fluoxepine group ,P<0.05,. Conclusion Mirtazapine is of good efficacy, rapid action, and less side effects in treatment of depression.
出处
《浙江医学》
CAS
2004年第12期885-887,共3页
Zhejiang Medical Journal