甲胎蛋白阳性胃癌的生物学特性

The clinicopathological features of alph-fetoprotein positive gastric cancer

目的探讨甲胎蛋白(AFP)阳性胃癌生物学特性和预后特点。方法将219例胃癌患者分成AFP阴性和阳性两组。比较两组肿瘤肉眼分类、大小、浸润深度、生长方式、肝脏和淋巴结转移程度、临床分期以及生存率。结果肝脏转移、多个淋巴结转移发生率及临床Ⅳ期胃癌比例,AFP阳性组均明显高于AFP阴性组(均P<0.01)。AFP阳性组1、3、5年生存率为55.6%、11.1%、5.6%,明显低于AFP阴性组的88.7%、60.3%、50.2%(均P<0.01)。结论AFP阳性胃癌是一种恶性程度高,易发生肝脏和淋巴结转移的预后不良的肿瘤。

Objective To investigate the clinicopathological features of alph-fetoprotein ,AFP, positive gastric carcinoma. Methods Two hundred and nineteen cases of gastric cancer were divided into AFP-positive group and AFP-negative group. The gross type, tumor diameter, invasion depth, infiltrating patterns, liver and lymph node metastasis, TNM stage and the disease prognosis were compared between the two groups. Results The rates of liver metastasis, number of metastatic lymph nodes, stageⅣ tumor in AFP-positive group were significantly higher than those in AFP-negative group ,P<0.01,. The 1, 3, 5 year- survival rates in AFP-positive group ,55.6%, 11.1%, 5.6%, respectively, were significantly lower than those in AFP-negative Group ,88.7%, 60.3%, 50.2% respectively, P<0.05,. Conclusion Alph-fetoprotein positive Gastric Cancer has significantly higher malignant behavior and poorer prognosis, which may be related to the frequent liver and lymph node metastasis.