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染色体核型分析在异基因造血干细胞移植中的应用 被引量：1

THE APPLICATION OF CHROMOSOME IN LEUKEMIA TREATED BY ALLO-HSCT
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摘要 目的:研究常规细胞遗传学在白血病造血干细胞移植方面的价值。方法:应用常规细胞遗传学方法定期检测白血病患者异基因造血干细胞移植前后常染色体、性染色体情况。结果:4例移植成功患者其中异性别3例性染色体表现为供者性染色体,原有异常消失;术后复发患者原有异常重现。结论:染色体可以作为异基因造血干细胞移植成功与否的标志和评价疗效的指标。 Objective: To investigate the value of classic cytogenetic analyse in monitoring the response to therapy in leukemia patients treated by allo-HSCT. Method: Studying of normal and sex chromosome by classic cytogenetic analyse in leukemia patients before and after treated by allo-HSCT. Results: Three of women patients had karyotype such as 46, XY showed donor's sex chromosome in 4 successful cases and primary abnormity disappeared. One relapsed case showed abnormal chromosome again. Conclusion: Classic cytogenetic analyse can be as the symbol of allo-HSCT succeed or not and guide line of the curative effect.
作者 胡杰英 宋永平 蒋东霞 魏旭东 范瑞华 周健 张莉 李莉
机构地区 河南省肿瘤医院中心实验室
出处 《白血病．淋巴瘤》 CAS 2004年第6期335-336,共2页 Journal of Leukemia & Lymphoma
基金 河南省科研院所专项资金资助课题(0241150403)
关键词 白血病 细胞遗传学 染色体 造血干细胞移植 异基因 Leukemia Cytogenetics Chromosome HSCT Allogeneic
分类号 R733.7 [医药卫生—肿瘤]
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参考文献2

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同被引文献10

  • 1Koreth J, Schlenk R, Kopecky K J, et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA, 2009, 301:2349-2361.
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  • 4Irvine DA, Shepherd JD. Recurrence of lymphoid blast crisis over 20 years after successful sibling allo-SCT for CML: short lived complete cytogenetic response to imatinib. Bone Marrow Transplant, 2009,44 : 267 -268.
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  • 7Pullarkat V, Slovak ML, Kopecky K J, et al. Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study. Blood, 2008,111 : 2563- 2572.
  • 8Lawler SD, Khokhar MT, Davies H, et al. Cytogenetic studies of leukemic recurrence in recipients of bone marrow allografts. Cancer Genet Cytogenet, 1990,47:249-263.
  • 9Schmidt-Hieber M, Blau LW, Richter G, et al. Cytogenetic studies in acute leukemia patients relapsing after allogeneic stem cell transplantation. Cancer Genet Cytogenet, 2010,198 : 135- 143.
  • 10Kelly M J, Meloni-Ehrig AM, Manley PE,et al. Poor outcome in a pediatric patient with acute myeloid leukemia associated with a variant t(8 ;21 ) and trisomy 6. Cancer Genet Cytogenet, 2009, 189 : 48-52.

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白血病．淋巴瘤
2004年 第6期

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