姜黄素β-环糊精包合物的制备工艺研究

Study on Preparation of the Inclusion Compound of Curcumin with β-Cyclodextrin

目的 :制备了姜黄素 β 环糊精包合物以增加难溶性药物姜黄素的溶解度和生物利用度。方法 :采用正交试验对包合物的制备条件进行了优化。采用荧光光谱法、薄层色谱法、相溶解度法对包合物进行了验证。结果 :制备姜黄素 β 环糊精包合物的最佳条件为姜黄素与 β 环糊精投料摩尔比为 1∶1,乙醇浓度为 4 0 % ,包合温度 5 0℃ ,反应时间 2h。结论 :该工艺制备的姜黄素 β 环糊精包合物的溶解度比姜黄素的溶解度增大了 10倍 ,本工艺适用于制备姜黄素 β

Objective: The inclusion compound of curcumin with β-CD was preparated to increase the solubility and bioavaliability of curcumin Methods: Prepare inclusion compound was studied with orthogonal design The inclusion compound was verified with fluorometry, TLC, and phase solubility Result: The best way to prepare inclusion compound are as follows: the molar ratio between curcumin and β-CD is 1∶1, temperture is 40℃, reaction time is 2h Conclusion: Solubility of inclusion compound is 10 times than curcumin