基于快速成形的β-磷酸三钙人工骨结构设计及制造

Structure Design and Fabrication of β-Τricalcium Phosphate Artificial Bone Based on Rapid Prototyping Technique

提出一种以计算机辅助设计(CAD)和光固化快速成形技术为基础的人工骨间接制造方法.应用CAD准确设计和控制人工骨内部结构,通过光固化快速成形技术制造相应的树脂模具,在模具中填充β-TCP生物陶瓷,经过烘干和热分解去模,获得了与设计相符的β-TCP生物陶瓷人工骨.该方法克服了传统人工骨构造方法中内部微管道结构不可控的缺点,为构造更有利于细胞-组织长入和成活的人工骨内部空间结构开辟了新路.实验证明,从人工骨的结构设计到最终的烧结成型,整个过程均是可控的,而且按照设计准则所构造的生物陶瓷人工骨内部空间结构,有助于促进其活化.

An indirect fabrication method for artificial bone is proposed based on CAD and stereolithography rapid prototyping(RP) technique. The internal structure of artificial bone is precisely designed and controlled, and the corresponding epoxy resin mould is manufactured with stereolithography RP technology. The β-tricalcium phosphate materials are filled into the mould and the bioceramic artificial bone with the internal structure consistent with design specification is achieved after drying and pyrolyzing. This method overcomes the defect that internal microchannel structure of traditional artificial bone is uncontrollable, and facilitates constructing a desired spacial structure of artificial bone where the cell/tissue ingrowth and survive are enhanced obviously. The experiments confirm that the whole procedure from structure design to final sintering is under control, and the internal spacial structure promotes the activiation of the artificial bone. .