治疗抑郁症3种药物方案的成本-效果分析

Cost-effectiveness Analysis of Three Therapeutic Regimens for Depression

目的:研究不同治疗方案对治疗抑郁症所产生的经济效果。方法:选择126例抑郁症患者,随机分为3组,分别给予盐酸多塞平片、西酞普兰片、盐酸氟西汀胶囊治疗,用药物经济学的成本-效果分析方法分析评价。结果:3组方案治疗效果的差异无统计学意义(P>0.05);西酞普兰方案和盐酸氟西汀方案的不良反应显著低于盐酸多塞平方案;盐酸多塞平方案治疗成本最低。结论:西酞普兰方案费用合理、起效快、疗效好、不良反应发生率低,是临床治疗抑郁症比较好的药物。

Objective: To study the economic effects of different medications in the treatment of depression. Method: 126 cases of patients with depression were randomly divided into three groups; Group Ⅰ (given doxepin hydrochloride tablets) , Group Ⅱ (goven citalopram tablets) and Group Ⅲ (given fluoxetine hydrchloride capsules) . The obtained data were evaluated by the pharmacoeconomic cost-effectiveness analysis. Result: No remarkable difference(P >0.05) was found in the curative effects of three groups, and the citalopram tablets and fluoxetine hydrchloride capsules were significantly less than that of doxepin hydrochloride tablets in the adverse reaction. The cost of therapy with doxepin was lowest. Conclusion: Citalopram tablets are a better drug of cost-effectiveness in the treatment of depression.