转化生长因子-β_1及其受体在大肠癌的表达及其意义

Significance of expression of transforming growth factor-β_1 and its receptor in colorectal carcinoma

目的探讨转化生长因子β1(TGF-β1)及其受体TβRⅡ在大肠癌发生发展过程中的作用。方法采用免疫组化SP法从蛋白水平分析TGFβ1、TβRⅡ在大肠腺瘤及大肠癌组织中的表达情况。结果TGFβ1蛋白阳性表达率在腺瘤组织为28.6%,大肠癌组织中为57.1%(P<0.05);TβRⅡ在大肠癌组织中的表达率为51.8%,低于腺瘤组织(90.5%)(P<0.01);TGFβ1、TβRⅡ表达的改变与大肠癌浸润深度、淋巴结转移相关(P<0.05或P<0.001)。结论TGFβ1的过度表达与大肠癌侵袭转移演进密切相关;TβRⅡ的失表达不仅有助于提高细胞对TGFβ1的生长抵抗,也增强了大肠癌的侵袭性。

Objective To investigate the role of transforming growth factor-β_1(TGF-β_1) and its receptorⅡ(TβRⅡ)expressions in colorectal carcinoma.Methods The S-P immunostaining technique was used to examine the expressions of TGF-β_1 and TβRⅡ in colorectal adenomas and carcinomas.Results TGF-β_1 was expressed positively in 28.6% colorectal adenoma tissues,while 57.1% in carcinoma(P<0.05);The TβRⅡ was expressed positively 51.8% in colorectal carcinoma tissues,which was lower than that in adenoma tissues(P<0.01);The expressions of TGF-β_1 and TβRⅡin colorectal tissues was correlated with colorectal carcinoma infiltration depth,lymph node metastasis (P<0.05).Conclusion The overexpression of TGF-β_1 was highly related to the invasion or metastasis of colorectal carcinoma;decreased expression of TβRⅡ was helpful not only to enhance cell growth resistance to TGF-β_1 but increase the invasion of colorectal carcinoma.