复发及多源发大肠癌多药耐药基因检测

Expression of Multidrug Resistance Gene in Relapsed Metastatic or Multisource Colorectal Carcinoma

目的 :研究多药耐药基因 (Mdr- 1)与复发及多源发大肠癌的关系。方法 :采用逆转录 -多聚酶链式反应 (RT- PCR)技术对81例复发和多源发大肠癌 Mdr- 1基因进行了检测。结果 :复发大肠癌 Mdr- 1基因表达率 6 1.5 % ,多源发大肠癌 Mdr- 1基因表达 5 5 .1% (P >0 .0 5 )。结论 :复发大肠癌 Mdr- 1基因表达的阳性和阴性与耐药与否的总符合率达 (2 8+17) /5 2 (P <0 .0 5 )。

Objective:To investigate the relationship between Mdr-1 gene and relapsed metastatic or multi-source colorectal carcinoma.Methods:Expression of mdr-1 gene was detected in 81 colorectal cancer cases based on PCR.Results:61.5% relapsed metastatic cases had positive expression of mdr-1 gene, 55.1% multi-source colorectal cancer cases had positive expression.Conclusion:The correspondence of gene expression multidrug resustance was (28+17)/52;(P<0.05)