摘要
头孢他美酯系一口服前体药,口服后在体内迅速水解为具有抗菌活性的头孢他美。报道了在偶极非质子性溶剂N,N-二甲基甲酰胺溶液中、三乙胺存在下,温度25-30℃,头孢他美与特戊酸酰溴甲酯反应生成头孢他美酯,并优化了酯化反应条件。产品结构用IR和1HNMR验证。
Cefetamet Pivoxil belongs to the class of orally absorbed prodrug esters.It was synthezed by cefetamet reacting with tertbutybrominacetate in the N,N-dimethyiformamide solution,in the presence of Et3N and at 25-30℃.The reaction condition was optimized and the structure was confirmed by 1 HNMR JR.
出处
《河北化工》
2004年第6期44-45,共2页
Hebei Chemical Industry
关键词
头孢他美酯
偶极非质子性溶剂
酯化反应
头孢他美
Cefetamet Pivoxil
dipolartic aprotic solvent
esterification traction
Cefetamet
