疏胆汤拆方治疗慢性胆囊炎的药效学观察

Pharmacodynamic Observation on Seperated Prescription Shudan Decoction in Treating Chronic Cholecystitis

目的 :探讨本方治病机理。方法 :将疏胆汤拆方为疏肝利胆组 (大柴胡汤去生姜、大枣加青皮、陈皮 )与活血化瘀组 (制大黄、丹参、郁金、石见穿 ) ,进行了拆方实验 ,比较疏胆汤与各拆方组在药效学上的差异。结果 :抑菌实验提示 ,疏胆汤及拆方组均有较好的抑制消化道常见细菌的作用。镇痛与抗炎实验表明三组中药均有明显的镇痛、抗炎作用 ,但疏胆汤优于各拆方组。利胆实验表明 ,三方均能增强大鼠泌胆功能 ,其中又以疏胆汤组为佳。说明疏肝利胆药与活血化瘀药合用 ,在利胆作用方面有协同增效作用 ,使胆汁分泌量显著增加 ,通过胆道内冲洗作用 ,解除胆汁瘀滞 。

Objective: To probe the treating mechanism of the prescription. Method: Shudan Decoction was seperated into the group of relieving the depressed liver and normalizing the gallbladder's function and the group of promoting blood circulation by removing blood stasis to compare the difference between Shudan Decoction and the seperated prescriptions in pharmacodynamics. Result: The bacteriostatic experiment indicated that Shudan Decoction and the seperated prescriptions have the function of resisting the common bacteria. The analgesic and anti-inflammatory experiment indicated that three groups of Chinese drugs all have the analgesic and anti-inflammatory function, but Shudan Decoction was much better than the seperated prescriptions. The cholagogic experiment showed that all the three groups could strengthen mice's biliation, Shudan Decoction was the best among them. Drugs relieving the depressed liver and normalizing the gallbladder's function along with drugs promoting blood circulation by removing blood stasis have the united building in the cholagogic function. And they can significantly increase the quantity of biliation and remove the stagnation of biliation and promote the vanishment of inflammation.