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神经节苷脂GM1神经保护机制的研究进展 被引量：32

Advances in the study of neuroprotective mechanisms of ganglioside GM1
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摘要 GM 1是含一个唾液酸的神经节苷脂 ,在脑中含量丰富 ,参与神经系统的发育过程 ,具有广泛的神经保护作用。本文综述了近 3年来GM 1参与突触的发生过程 ,激活酪氨酸激酶受体———Trk受体 ,调节细胞内Ca2 + 的平衡 ,降低Aβ在脑内的沉积及其毒性作用 ,减少活性氧的产生 ,促进Na+ ,K+ ATPase活性等神经保护机制方面的最新报道。 The monosialic acid ganglioside GM1 is rich in brain, which participates in the development process of the nerve system and plays wide neuroprotective roles. This article reviews recent reports about six neuroprotective mechanisms including: activating tyrosine kinase receptor——Trk receptor, modulating Ca 2+ homeostasis in cells, reducing the deposition of Aβ and its toxic roles in brain, inhibiting the production of reactive oxygen species, enhancing the activity of Na+,K+-ATPase.
作者 张卿 左萍萍
机构地区 中国医学科学院基础医学研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2004年第12期1329-1333,共5页 Chinese Pharmacological Bulletin
关键词 GM1 神经保护机制 GM1 neuroprotective mechanisms
分类号 R-05 [医药卫生] R338.13 [医药卫生—人体生理学]
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参考文献25

  • 1Allende ML and Proia RL. Lubricating cell signaling pathways with gangliosides[J]. Current Opinion in Structural Biology, 2002,12(5):587-92.
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同被引文献256

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中国药理学通报
2004年 第12期

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