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TLRs与抗结核免疫

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摘要 TLRs是近来在哺乳动物中发现的同源于果蝇Toll的蛋白分子 ,在宿主的天然免疫中具有重要的作用。最近的研究表明 ,TLRs是介导宿主对结核杆菌的识别及抗结核免疫反应的关键分子。目前对TLRs基因敲除小鼠的研究有望进一步揭开各个TLRs在抗结核免疫中的确切作用机制。
出处 《国外医学(呼吸系统分册)》 2004年第6期371-373,共3页 Section of Respiratory System Foreign Medical Sciences
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  • 1Ray A,Chatterjee NS,Bhattacharya SK,et al.Porin of Shigella dysenteriae enhances mRNA levels for Toll-like receptor 2 and MyD88,up-regulates CD80 of murine macrophage,and induces the release of interleukin-12.Immunol Med Microbiol,2003,39:213-219.
  • 2Faure E,Equils O,Sieling PA,et al.Bacterial lipopolysaccharide activates NF-B through Toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells.Differential expression of TLR-4 and TLR-2 in endothelial cells.J Biol Chem,2000,275:11058-11063.
  • 3Hertz CJ,Kiertscher SM,Godowski PJ,et al.Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2.J Immunol,2001,166:2444-2450.
  • 4Underhill DM,Ozinsky A.Toll-like receptors:key mediators of microbe detection.Curr Opin Immunol,2002,14:103-110.
  • 5Spies B,Hochrein H,Vabulas M,et al.Vaccination with plasmid DNA activates dendritic cells via toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice.J Immunol,2003,171:5908-5912.
  • 6Tsuji S,Matsumoto M,Takeuchi O,et al.Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of Toll-like receptors.Infect Immun,2000,68:6883-6890.
  • 7Re F,Strominger JL.Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells.J Biol Chem,2001,276:37692-37699.
  • 8Nau GJ,Richmond JF,Schlesinger A,et al.Human macrophage activation programs induced by bacterial pathogens.Proc Natl Acad Sci,2002,99:1503-1508.
  • 9Bogdan C.Nitric oxide and the immune response.Nat Immunol,2001,2:907-916.
  • 10Jones BW,Means TK,Heldwein KA,et al.Different Toll-like receptor agonists induce distinct macrophage responses.J Leukoc Biol,2001,69:1036-1044.

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