摘要
以3 羟基丁酮作为起始原料,经过酰氯化、成环、脱氯化氢、溴化合成4 溴甲基 5 甲基 1,3 二氧戊环 2 酮,再和氨苄青霉素反应合成伦氨苄西林盐酸盐。其含量99%,总收率(以3 羟基丁酮计)37.3%。
4-bromomethyl-5-methyl-1,3-dioxolen-2-one was synthesized from 3-hydroxy-butanone by phosgenation, cyclization, dehydrochlorination and bromination. Lenampicillium hydrochloride was synthesized by the reaction of 4-bromomethyl-5-methyl-1,3-dioxolen-2-one and ampicillin.
出处
《精细化工中间体》
CAS
2004年第6期35-36,共2页
Fine Chemical Intermediates