芳亚甲基丙二腈和4-羟基喹啉-2-酮反应的研究

Study on the Reaction of Arylmethylidenemalononitriles with 4-Hydroxy-1,2-dihydroquinolin-2-one

以芳亚甲基丙二腈和 4 羟基喹啉 2 酮为原料 ,在六氢吡啶催化下以乙醇为溶剂 ,80℃合成了一系列新的 2 氨基 3 氰基 4 芳基 5 ,6 二氢化 4H 吡喃并 [3 ,2 c]喹啉 5 酮衍生物 ,反应条件温和 ,产率较高 ,并通过单晶X射线衍射分析确证产物的结构 .

A series of new 2-amino-3-cyano-4-aryl-5, 6-dihydro-4H-pyrano [3, 2-c] quinolin-5-one derivatives were synthesized by the reaction of arylmethylidenemalononitriles with 4-hydroxy-1,2-dihydroquinolin-2-one in ethyl alcohol at 80 degreesC catalyzed by piperidine in good yields. The structure of the product was confirmed by X-ray analysis.