超声辐射合成5,7-二取代-2-(5-芳基-2-呋喃甲酰亚胺)-[1,2,4]-噻二唑并[2,3-a]嘧啶衍生物及其生物活性研究

Ultrasonically Irradiated Synthesis and Bioactivity of 5,7-Disubstituted-2-(5- aryl-2-furoylimino)-[1,2,4]-thiadiazolo[2,3-a]pyrimidine Derivatives

利用相转移催化法在超声辐射下合成了 8种未见文献报道的 5 ,7 二取代 2 (5 芳基 2 呋喃甲酰亚胺 ) [1,2 ,4] 噻二唑并 [2 ,3 a]嘧啶衍生物 .其结构经元素分析、IR和1HNMR得到确证 .该法具有操作简便 ,反应时间短等优点 .初步的生物活性测试结果表明部分化合物具有一定除草活性 .

Eight new 5,7-disubstituted-2-(5-aryl-2-furoylimino)-[1,2,4]-thiadiazolo[2,3-a]pyrimidine derivatives were synthesized under ultrasonic irradiation. All of them are new compounds and their structures were exactly confirmed by IR, 1H NMR spectra and elemental analysis. Our method using the ultrasonic irradiation under the condition of phase transfer catalyst (PTC) has the advantages of short reaction time and good yield. The preliminary biological tests show that some of the target compounds have some inhibitory activities against weeds.