水溶性药物巯甲丙脯酸/Si-MCM-41载药新体系的制备与缓释作用研究

Preparation and Sustained Release of a New Water-soluble Drug Carrier System Captopril/Si-MCM-41

采用浸渍法将水溶性的抗高血压药物巯甲丙脯酸组装到 Si-MCM-41的孔道中 ,药物组装量达3 3 .99% [m(药物 ) /m(载体 ) ];用 XRD,IR和固体紫外法对药物组装体进行了表征 ;通过测定组装体在体外模拟人工胃液中的释放速率 ,表明制得了巯甲丙脯酸

Water-soluble anti-hypertension drug Captopril was incorporated in Si-MCM-41 channel by using impregnation wetness method, the mass fraction of drug[m(drug)/m(Si-MCM-41)] was 33.99%. Captopril/Si-MCM-41 assembly was characterized by XRD, IR, UV-visible technique. The sustained release profile was observed by soaking the assembly in vitro simulated stomach fluid. The results suggest that a Captopril/Si-MCM-41 sustained release system was obtained.