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胰岛素信号转导与肝胰岛素抵抗 被引量：15

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摘要 主要阐述胰岛素信号转导缺陷与肝胰岛素抵抗的关系.IRS-2是肝胰岛素信号转导核心介子,IRS-2基因的缺失或IRS-2信号网络上一些关键信号分子的异常改变,都将导致肝胰岛素信号转导能力减弱,出现肝胰岛素抵抗.研究发现诸多因素,如蛋白和脂类磷酸酶,脂源性细胞因子、游离脂肪酸均可影响肝胰岛素信号转导.肝胰岛素信号转导缺陷参与胰岛素抵抗综合征有关的非酒精性脂肪肝的发生,其分子机制成为目前研究的重点之一.
作者 祝炼 袁莉
机构地区 华中科技大学同济医学院附属协和医院内分泌科
出处 《世界华人消化杂志》 CAS 2004年第10期2420-2423,共4页 World Chinese Journal of Digestology
关键词 胰岛素信号转导 肝胰岛素抵抗 蛋白 脂类磷酸酶 脂源性细胞因子
分类号 R587.1 [医药卫生—内分泌]
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参考文献19

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共引文献17

同被引文献190

引证文献15

二级引证文献130

世界华人消化杂志
2004年 第10期

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