期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Meynert基底核的老龄改变及相关因素

Age-related Changes of Basal Nucleus of Meynert and Its Related Factors
下载PDF
导出
摘要 年龄的增长将伴随认知功能不同程度的衰退或障碍。近年来对有认知功能障碍疾病的研究表明 ,在老龄认知功能障碍时 ,基底前脑Meynert基底核 (简称NBM )内的胆碱能神经元显著丢失 /萎缩 ,不仅其本身的代谢活性减低而且还累及到NBM投射区 (即皮质 )的形态及功能的改变。NBM内神经元退行性改变的机制虽尚未明确 ,但动物实验表明 ,这很可能是神经元营养供应不足或缺乏的结果。本文将对NBM神经元退行变及其神经营养机制作进一步的讨论。 Declines in cognitive function accompany normal aging i n humans. More recent studies have demonstrated that normal aging and cognitive dy sfunction is associated with significant cell loss/atrophy and reduction in cell metabolic functions in nucleus basalis of Meynert (NBM). The changes of NBM als o affected the morphology and functions of neurons in cortex. Although the mecha nism of these age-related changes remained poorly defined, the experimental stud ies from animals showed that neurotrophic dysfunction would be responsible for i t. In this review, we discussed these age-related changes and its neurotrophic mechanism in details.
作者 赵海花 赖红 吕永利
机构地区 中国医科大学解剖学教研室
出处 《解剖科学进展》 CAS 2004年第4期371-374,共4页 Progress of Anatomical Sciences
关键词 退行性改变 胆碱能神经元 认知功能障碍 老龄 相关因素 基底前脑 神经营养 机制 制作 萎缩
分类号 Q421 [生物学—神经生物学] R749 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献31

  • 1Harkany T, Dijkstra IM, Oosterink BJ, et al. Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca2+ antagonist nimodipine [ J ]. Neuroscience
  • 2Salehi A, Verhaagen J, Dijkhuizen PA, et al. Co-locazation of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease [J]. Neurosci, 1996,75 (2): 373 -387.
  • 3Bachman C, Rose GM, Hoffer BJ, et al. Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy [J]. J Neuronsci, 1996,16(17): 5437 -5442.
  • 4Strada O, Vyas S, Hirsch EC, et al. Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer's disease: an in situ hybridization study [J]. Proc Natl Acad Sci USA, 1992, 89(20):9549-9553.
  • 5Kojima M, Takahashi N, Ikeuchi T, et al. Nerve growth factor (NGF)-mediated up-regulation of low-affinity NGF receptor gene expression in cultured basal forebrain cholinergic neurons from postnatal 3-day-old rats [J]. Brain Res Mol Brain Res, 1992, 16 (3
  • 6Boncristiano S, Calhoun ME, Kelly PH, et al. Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis[J]. J Neurosci, 2002, 22(8) :3234 -3243.
  • 7Wellman CL, Sengelaub DR. Alterations in dendritic morphology of frontal cortical neurons after basal forebrain lesions in adult and aged rats [J]. Brain Res, 1995,669(1):48-58.
  • 8Wellman CL, Sengelaub DR. Cortical neuroanatomcial correlates of behavioral deficits produced by lesion of the basal forebrain in rats [J]. Behav Neural Biol, 1991,56(1):1 -24.
  • 9Selden NR, Gitelman DR, Salamon-Murayama N, et al. Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain [J]. Brain, 1998,121(pt 12): 2249-2257.
  • 10Francis PT, Palmer AM, Snape M, et al. The cholinergic hypothesis of Alzheimer's disease: a review of progress [J]. J Neurol Neurosurg Psychiatry, 1999,66(2): 137 - 147.
解剖科学进展
2004年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部