母婴ABO血型不合与新生儿溶血病的关系

Relationship between pregnant women with ABO blood group incompatibility and hemolytic disease of newborn

目的 探讨O型孕妇血清IgG抗体效价与新生儿溶血病的关系。 方法 对丈夫血型为A型 ,B型或AB型的 75 4例O型孕妇进行血清IgG抗A(B)抗体水平检测 ,同时对IgG抗A(B)≥ 6 4的孕妇所生的新生儿做HDN免疫血清学检查。 结果 75 4例O型孕妇中产前IgG抗A(B)≥ 6 4的有 2 87例 ,其所生新生儿发生新生儿溶血病的例数为 31例。结论 新生儿溶血病发病率与孕妇血清IgG抗A(B)效价的高低成正相关。

Objective To study the relationship between serum antibody IgG level of pregnant women with type O and hemolytic disease of newborn(HDN). Methods Prenatal immunohematological tests were done for 754 pregnant women with type O whose husbands were not type O. Meanwhile, HDN immunohematological tests were also done for the newborns whose mothers' antibody IgG titer was ≥64. Results Among the 754 pregnant women, there were 287 with type O and antibody IgG titer ≥64. Of these women' newborns,31 suffered from HDN. Conclusion The incidence of HDN is positively correlated to the level of serum antibody IgG in pregnant women.