原发性高血压伴胰岛素抵抗及高尿酸血症的治疗

The Drug Treatment of Essential Hypertension in Patients with Insulin Resistance and High Uric Acid

目的 :观察苯那普利与缬沙坦对原发性高血压合并胰岛素抵抗 (IR)以及高尿酸血症 (HU)患者相关参数的影响。方法 :60例原发性高血压合并胰岛素抵抗以及高尿酸血症患者分成苯那普利治疗组 (A组 )、缬沙坦治疗组 (B组 ) ,疗程 8周 ,观察治疗前后两组间血压、空腹血糖、血清胰岛素水平、血尿酸、胰岛素敏感指数 (ISI)的变化。结果 :两组治疗前后收缩压、舒张压、空腹血清胰岛素水平皆有显著下降 ,胰岛素敏感指数 (ISI)与治疗前相比有明显上升 ,缬沙坦组血尿酸较治疗前有明显下降 ,而苯那普利组差异无显著性。结论 :苯那普利与缬沙坦对于合并有胰岛素抵抗以及高尿酸血症的原发性高血压患者皆有降压和改善IR作用 。

Objective:To study the effects of benazepril and Valsartan on essential hypertension in patients with insulin resistance (IR) and high uric acid (HU).Methods:60 patients with IR and HU were divided into two groups- benazepril treatment group and Valsartan treatment group. Before treatment and after 8 weeks of treatment, blood pressure, plasma levels of glucose, insulin, uric acid, insulin sensitive index (ISI) were detected.Results:In two groups, blood pressure, fasting glucose, insulin were notably reduced, ISI was markedly increased. Plasma level of uric acid was reduced significantly in Valsartan group, but slightly in benazepril group.Conclusions:Valsartan and benazepril are effective on essential hypertension in patients with IR. But Valsartan may be a better selection to essential hypertension in patients with IR and HU.