摘要
磷原子同碳原子一样,当四个配位体各不相同时,分子旋光性不同。有机膦药物都是膦酸酯类衍生物,分子中磷有四个配位体。所有含磷药物都有光学异构体。不同异构体的生理活性差异很大。这一点引起磷化学家、药物化学家及军事学家们浓厚的兴趣。
A method of separating diastereoisomers of hexacycliophosphoamide by high performance liquid chromatography has been established. The fractions from chromatographic separation were identified by nuclear-magnetic resonance. mass spectrometry and X-ray diffraction.
出处
《色谱》
CAS
CSCD
北大核心
1993年第2期116-117,共2页
Chinese Journal of Chromatography