含利福喷丁方案对结核病的预防性治疗效果研究

Study on treatment effects of rifapentine preventing tuberculosis for positive PPD reaction

目的 :探讨含利福喷丁方案对结核菌素强阳性患者预防性治疗的接受性及治疗效果。方法 :追踪观察结核菌素强阳性患者的利福喷丁预防性治疗过程 ,了解方案的可接受性及结核病发病情况。结果 :结核病高危险患者对含利福喷丁方案预防性治疗的接受率 83 9% ,药物不良反应发生率 7 2 % ;服用异烟肼预防性治疗组接受率 72 5 % ,药物不良反应发生率 10 2 %。活动性结核病 2年及 5年累积发病率在含利福喷丁方案预防性治疗组分别为 2 67‰、6 44‰ ,与服用异烟肼组无显著性差异 ,但明显低于未进行预防性治疗组。结论 :含利福喷丁的预防性治疗方案 ,对高危人群结核病的发生不仅具有较好的人群可接受性 ,同时不良反应率低 ,与服用异烟肼预防性治疗效果接近 ,具有较好的结核病预防作用。

Objective: To reveal the treatment effects of rifapentine preventing tuberculosis.Methods: To observe the course continually treated positive PPD reaction with the scheme including rifapentine.Results: The acceptable rate was 83.9%.The rate of adverse drug reactions was 7.2%.The active tuberculosis incidence was 2.67 ‰ and 6.44 ‰ respectively during two and five years.The total active tuberculosis incidence was lower in using rifapentine group than control group.Conclusion: It was feasible and effective that patients of positive PPD reaction were treated with the plan consisting of rifapentine for three month preventing tuberculosis.