低分子肝素治疗进展脑梗死疗效观察

Effect of Low Molecular Weight Heparin on Patients with Progressive Cere bral inf arction

目的 观察低分子肝素治疗进展性脑梗死的临床效果。方法 分析 17例应用低分子肝素治疗的进展性脑梗死患者与未用低分子肝素治疗的 2 3例作为对照组。比较两组治疗前后纤维蛋白原和神经功能缺损评分。结果 两组临床治愈率分别为 88.2 %和 5 2 .2 % ,统计学比较有显著差异 (χ2 =5 .72 ,P <0 .0 5 )。治疗组在治疗前后纤维蛋白原变化有显著性差异 (P <0 .0 1)。结论 低分子肝素治疗进展性脑梗死临床效果确切、安全无副作用。

Objective To investigate the clinical effect of low molecular we ight heparin on patients with progressive stroke. Methods 17 patients with pro gressive stroke were treated with low molecular weight heparin, and 23 patients in control group were treated without low molecular weight heparin. The concentr ation of plasma fibrinogen and the score of neurologic impairment in experimenta l group were compared with control group. Results The cure r ates were 88.2% in treatment group and 52.2% in control group, the difference was significant (P <0 .05). In addition, the difference of plasma fibrinogen between two groups was si gnificant (P<0.01). Conclusions Low molecular weight he pa rin is safe and effective in treating progressive stroke without side effect.