深圳地区汉族人凝血因子XIIIVal34Leu基因多态性研究

Va134 Leu gene polymorphism of factor XIII in Han people in Shenzhen

目的 :研究深圳地区汉族人凝血因子 XIII Val3 4Leu基因多态性特点。方法 :应用 PCR技术结合 Hin6I酶切分析、琼脂糖凝胶电泳 ,研究深圳地区 10 8名汉族人凝血因子 XIII Val3 4Leu基因多态性特点。结果 :深圳地区汉族人等位基因 Val3 4与等位基因L eu3 4的频率分别为 99.0 7%和 0 .93 %。 Val/ Val纯合子、Val/ leu杂合子和 L eu/ L eu纯合子的频率分别为 98.15 % ,1.85 %和 0。结论 :深圳地区汉族人凝血因子 XIII L eu3 4等位基因频率比高加索人群低。

Objective: To investigate Va134 Leu gene polymorphism of factor XIII (FXIII) in Han people in Shenzhen. Methods: Va134 Leu gene polymorphism of FXIII in 108 Han persons in Shenzhen was detected by PCR, Hin 6I enzyme analysis and agarose gel electrophoresis. Results: The frequencies of Va134 and Leu34 alleles were 99.07% and 0.93%, respectively; and those of Val/Val homozygote, Val/Leu heterozygote and Leu/Leu homozygote were 98.15%, 1.85% and 0, respectively. Conclusion: The frequency of FXIII Leu34 allele in Han people in Shenzhen is lower than that in Caucasian.