阿莫林、叶酸联合治疗萎缩性胃炎疗效观察

To Evaluate Curative Effect of Amoxycillin and Folate for Chronic Atrophy Gastritis

目的 :研究阿莫林联合叶酸治疗慢性萎缩性胃炎 (CAG)的疗效及对萎缩腺体的组织学影响。方法 :治疗组及对照组连续服药 3个月为一疗程 ,服药前后行胃镜和胃粘膜病理组织学检查。每两周复诊病情变化。病理组织学检查以萎缩、肠化、非典型增生为参数来评价 ,临床症状以上腹部疼痛、嗳气、饱胀感分项统计。结果 :治疗组可明显改善CAG的临床症状 ,有效率分别为上腹痛 76 .4 7% ,嗳气 74 .5 1% ,上腹部饱胀感 80 .39% ;对照组有效率分别为上腹痛 30 .4 3% ,嗳气39.13% ,上腹部饱胀感 34.78%。病理组织学检查胃粘膜上皮有不同程度的改善 :治疗组有效率分别为轻度 72 .5 5 % ,中度 6 8.6 3% ,重度 6 2 .75 % ;对照组有效率分别为轻度 17.39% ,中度 13.0 4 % ,重度 4 .35 %。结论 :阿莫林联合叶酸治疗萎缩性胃炎效果理想 ,可以明显改善临床症状 ,使萎缩的腺体部分逆转。

s Aims:The aim of this study was to Evaluate curative effect of Amoxycillin and Folate for chronic atrophy gastritis(CAG) and to investigate effect of atrophied gland in histology.Methods:Endoscopy was taked before and after the treated group and the compared group dose for three month.In the same time,histology of gastric mucosa was did.To track record the state of an illness every two weeks.Parameter of histology was used to atrophy,sintestinal metaplasia and nonrepresentative hyperplasia.Clinical symptom was of statistic by up bellyache,haw and fill.Results:The treated group can large improve clinical symptom of CAG.Respectively efficient rate was 76.47%,74.51% and 80.39%.But the respectively efficient rate of compared group was only 30.43%,39.13% and 34.78%.Histology of gastric mucosa have large improved.Respectively efficient rate of the treated group was 72.55%(light degree),68.63%(middle degree),62.75%(heavy degree),but the compared group was only 17.39%,13.04% and 4.35% respectively.Conclusion:The therapy of Amoxycillin and Folate for chronic atrophy gastritis was very efficient.It can improve the clinical symptom in evidence and recover the atrophied gland.