盐酸氯普鲁卡因与利多卡因硬膜外麻醉的临床观察

Evaluation The Efficacy of Chlorprocaine And Lidocaine in Epidural Anesthesia

目的 :评估盐酸氯普鲁卡因与利多卡因用于硬膜外麻醉的效应。方法 :6 0例剖宫产手术病人 ,随机分为试验组 (3%盐酸氯普鲁卡因 ,n=30 )和对照组 (2 %利多卡因 ,n=30 )。均硬膜外 (L2～ 3)试验量 4 ml后 5 min,一次性注入 12 ml(含肾上腺素 1∶ 2 0万 )。观察麻醉起效时间、痛觉消失时间、运动阻滞时间、痛觉恢复时间、运动恢复时间以及不良反应。结果 :试验组麻醉起效时间、痛觉消失时间、运动阻滞时间均快于对照组 (P<0 .0 5 ) ,痛觉恢复时间两组一致 ,运动恢复时间试验组快于对照组 (P<0 .0 5 ) ;两组均未见明显不良反应。结论 :3%盐酸氯普鲁卡因用于硬膜外麻醉起效快 ,感觉和运动阻滞效果好 ,无明显不良反应 ,较 2 %利多卡因优。

Objective To evaluate the effects of chlorprocaine and lidocaine in epidural anesthesia.Methods Sixty parturients were randomly designed to test group (3 % chlorprocaine,n=30) and control group (2 % lidocaine,n=30). Five minutes after 4 ml anesthetic test volume into epidural space(L 2～3),a bolus of 12 ml anesthetic was given to eath patient. Results The onset time of epidural blockade, pain free and motor free in test group was shorter than that in control group (P<0.05); The onset time of pain recovery was similar in both groups. The onset time of motor recovery was faster significantly than that in control group (P<0.05); The side effects were not observed in both groups.Conclusion The 3 % chlorprocaine is faster in onset, is well in nerve blockade, and has little side effect than the 2 %lidocaine for epidural anesthesia.