自身免疫性甲状腺疾病血、尿β_2-微球蛋白水平及其临床意义

CONCENTRATION OF SERUM AND URINARY BETA-2-MICROGLOBULIN IN AUTOIMMUNE THYROID DISEASE AND CLINICAL APPLICATION

用放免法测定76例自身免疫性甲状腺疾病及正常对照组的血、尿β_2-微球蛋白水平。结果:Graves病未缓解组、桥本氏病组血、尿β_2-微球蛋白较对照组明显升高(P<0.001),Graves病缓解组、特发性甲减组与对照组差异无显著性(P>0.05)。Graves病缓解组较Graves病未缓解组明显降低(P<0.01)。提示β_2-微球蛋白水平测定可做为自身免疫性甲状腺疾病诊断、疗效观察及了解其免疫状态的一项指标。

Serum and urinary beta-2-microglobulin(beta-2-m)levels were measured by radioimmunoassay in 76 patients with autoimmune thy- roid disease and 21 healthy control subjects.The patients were divided into four groups.Group A:26 patients with unremitted Graves disease,group B:19 patients with remitted Graves disease,group C:17 patients with chronic lymphocytic thyroiditis,group D:14 patients with primary hypo- thyroidism.The levels of serum and urinary beta-2-m were significantly increased in group A and in group C compared to the controls.The levels of serum and urinary beta-2-m in group B and in group D were not different from that of the controls.The serum and urinary beta-2-m were significantly decreased in group B compared to group A.It′s concluded that serum and urinary beta-2-m may be a useful laboratory indication of diagnosis and of response to treatment in autoimmune thyroid disease.