铝碳酸镁和莫沙必利对胆汁反流性胃炎的疗效观察

The curative effect of hydrotalcid and mosapride on bile-reflux gastritis

目的探讨铝碳酸镁与莫沙必利对胆汁反流性胃炎的疗效及胃内胆汁的影响。方法60例胆汁反流性胃炎,经电子胃镜证实,并随机分为3组。M组服用莫沙必利5mg,3次/天;T组服用铝碳酸镁1.0g,3次/天;M+T组同时服用莫沙必利和铝碳酸镁。治疗4周后观察腹痛、腹胀、呕吐胆汁等症状变化,所有患者复查胃镜。结果治疗后M、T、M+T3组患者症状均明显减轻(P<0.01),有效率分别为90%、100%和100%。内镜下胆汁反流减少,消失率分别为85%、90%和95%。结论铝碳酸镁和莫沙必利合用能有效治疗胆汁反流性胃炎。

Objective:To investigate the curative effect of hydrotalcid and mosapride on bile-reflux gastritis and its influence on intragastric bile.Methods:60patients with bile-reflux gastritis documented by electronstomachoscopy were randomly divided into3groups equally,which were treated with mosapride5mg three times daily;hydrotalcid1.0g three times daily and both drugs respectively.The changes of the symptoms,including abdominal pain,abdominal distention,nausea and vomiting bile were observed before and four weeks after treatment.The review of electronstomachoscopy was performed in all patients.Results:The severity of all the symptoms in the three groups decreased obviously after treatˉment(P<0.01),the effective rate was90%,100%and100%respectively.Bile reflux decreased under endoscope,the disappearance rate was85%,90%and95%respectively.Conclusion:Hydrotalcid combined with mosapride can effectively treat bile-reflux gastritis.