Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries 被引量：1

Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries

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摘要 Eleven (S)-(-)-bishydrocarbyl-(1-alkanoylpyrrolidin-2-yl)-methanol derivatives of three types were synthesized from L-proline, asymmtrically selective alkylation products were obtained by LDA treatment and alkylation using methyl 2-bromoethyl ether, and three types of chiral α-substituted-γ-butyrolactones were obtained by hydrolyzing the alkylation products, with %e.e. being up to 89 percent. Eleven (S)-(-)-bishydrocarbyl-(1-alkanoylpyrrolidin-2-yl)-methanol derivatives of three types were synthesized from L-proline, asymmtrically selective alkylation products were obtained by LDA treatment and alkylation using methyl 2-bromoethyl ether, and three types of chiral α-substituted-γ-butyrolactones were obtained by hydrolyzing the alkylation products, with %e.e. being up to 89 percent.

作者 JiaChengNING ShuMAO YeDiGUAN

机构地区 DepartmentofChemistry

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第1期17-19,共3页 中国化学快报（英文版）

关键词 Asymmetric synthesis α-substituted-γ-butyrolactone. Asymmetric synthesis, α-substituted-γ-butyrolactone.

分类号 O623.624 [理学—有机化学]

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Chinese Chemical Letters

2005年第1期

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Asymmetric Synthesis of α-Substituted-γ-butyrolactone Empolying Prolinol Type of Auxiliaries 被引量：1

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