胸腺肽致中枢神经系统脱髓鞘病2例

CNS demyelinating disease in association with thymopeptide:2 case reports

A 33-year-old woman was hospitalized with somnolence and incoherent speech for 5 days. She was given thymic peptide 20mg by intramuscular injection daily in order to prevent SARS before the admission. Physical examination showed somnolence, inability of understanding, orientation and calculation, tendon hyperreflexia and positive Babinski reflex. MR showed multiple pathological changes throughout her periventricular and subcortical white matter. She was diagnosed as acute demyelinating disease and treated with prednisolone. Her condition improved after treatment. A 52-year-old man was hospitalized with numbness of right hand for 3 months and weakness of right limbs for 11 days. The patient was given thymic peptide 20mg by intramuscular injection once a week in order to prevent SARS. After the second administration, he had low fever, and the above-mentioned numbness and weakness occurred. MR showed large areas of T1 and T2 hyperintensity around ventricles of brain. He was diagnosed as multiple sclerosis, and his condition was improved after treatment.