摘要
过去10年大量证据证实了胎儿生长迟缓与后期的代谢及心血管并发症的联系。胎儿生长迟缓和营养不良可影响胰岛素的分泌和胰岛β细胞的功能,并可造成胰岛素抵抗,胰岛素抵抗是上述代谢和心血管并发症发病的始动环节。其发生机制可能与宫内不良环境的影响、某些基因的变异以及激素轴紊乱等有关。该文就当前的研究进行综述。
Large amount of evidences over the past decade have proved an association between reduced fetal growth and the later development of metabolic and cardiovascular diseases. Reduced fetal growth and malnutrition can affect the secretion of insulin and function of β cell,and thus result in insulin resistance. Insulin resistance is an initial factor which responsible for the above diseases and complications. The development of insulin resistance may be associated with a detrimental fetal environment,mutation of some genes, disorder of hormonal axes and etc. This article reviewed current epidemiological and clinical evidences and possible mechanism about association between reduced fetal growth and insulin resistance.
出处
《国外医学（妇幼保健分册）》
2004年第6期321-323,共3页
Foreign Medical Sciences (Section of Maternal and Child Health)
关键词
婴儿
胎儿生长迟缓
胰岛素抵抗
infant
reduced fetal growth
insulin resistance
