PSA、PSAD、PSAT在前列腺偶发癌诊断中的的意义

The significance of serum prostate specific antigen prostate specific antigen density and density of the transition zone in incidental adenocarcinoma of prostate

目的 探讨血清前列腺特异性抗原 (PSA)及其密度 (PSAD)和移行带密度 (PSAT)在前列腺偶发癌诊断中的意义。方法 选择经手术证实的前列腺偶发癌患者 2 7例和前列腺增生症 (BPH)患者 3 2例 ,比较其 PSA、PSAD、PSAT指标。结果 前列腺偶发癌组和 BPH组 PSA分别为 (5 .0 3± 1 .61 )、(4 .3 1± 1 .5 2 ) μg/ L,差异无显著性 (P >0 .0 5 ) ;PSAD分别为 (0 .1 7± 0 .1 6)、(0 .0 9± 0 .1 3 )μg/ L ,差异有显著性 (P <0 .0 5 ) ;PSAT分别为 (0 .2 9± 0 .1 0 )、(0 .1 5± 0 .1 6) μg/ L,差异具有非常显著性 (P <0 .0 1 )。结论 PSAD、PSAT对前列腺偶发癌的诊断具有重要价值 ,其中尤以 PSAT更具预测价值。

Objective To define the role of serum prostate specific antigen(PSA),PSA density(PSAD) and PSA density of the transition zone(PSAT) in incidental adenocarcinoma of prostate.Methods The data of 27 patients with incidental adenocarcinoma of prostate and 32 patients with BPH were collected,then compared PSA,PSAD,PSAT between the two groups.Results The mean PSA in incidental adenocarcinoma of prostate group and BPH group were(5.03±1.61) and(4.31±1.52) ,respectively ,with no statistic difference( P <0.01). The mean PSAD in incidental adenocarcinoma of prostate group and BPH group were (0.17±0.16) and(0.09±0.13) respectively with statistic difference( P <0.05). The mean PSAT in incidental adenocarcinoma of prostate group and BPH group were(0.29±0.10) and(0.15±0.16) respectively with obviously statistic difference( P <0.01).Conclusions The result suggest PSAD,PSAT could be used to distinguish incidental adenocarcinoma of prostate and BPH.