HIV-1逆转录酶耐核苷类药物突变新进展
被引量:2
Review of NRTIs-resistant mutations on HIV-1 reverse transcriptase
摘要
随着抗逆转录病毒药物 (ART)的不断开发和高效抗逆转录病毒疗法 (HAART)的应用和推广 ,艾滋病发病率和死亡率明显降低。然而 ,对一种或多种抗逆转录药物耐药的HIV_1变异株的出现成了影响HAART治疗效果的主要因素之一。加强对HIV_1耐药突变及其相互关系的理解对临床治疗有重要的意义 ,本文将对目前HIV_1逆转录酶耐核苷类药物突变进展进行综述。
参考文献10
-
1Gotte M,Arion D,Parniak MA,et al. The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis. J Virol,2000,74(8) :3579-3585.
-
2Walmsley S, Bernstein B, King M, et al. Lopinaqr-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med, 346 (26):2039-2046.
-
3Eron J J, Benoit SL, Jemsek J, et al. Treatment with lamivudine, zidovudine,or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter. North American HIV Working Party. N Engl J Med, 1995,333(25): 1662-1669.
-
4Deeks SG, Martin JN, Hoh R, et al. Continued reverse transcriptase inhibitor therapy is sufficient to maintain short-term partial suppression of multidrug resistant viremia. In Program and Abstracts of the Tenth Conference on Retroviruses and Opportunistic Infections, Boston, MA,2003. Abstract 640, p286. Foundation for Retrovirology and Human Health, Alexandria, VA, USA.
-
5Maguire M, Gartland M, Moore S, et al. Absence of zidovudine resistance in antiretroviral-naive patients following zidovudine/lamivudine/protease inhibitor combination therapy: virological evaluation of the AVANTI 2 and AVANTI 3 studies. AIDS,2000,14(9): 1195-1201.
-
6Larder B.Mechanisms of HIV-1 drug resistance. AIDS,2001,15 (S5):S27-S34.
-
7Quan Y, Gu Z, Li X, et al. Endogenous reverse transcriptase assays reveal synergy between combinations of the M184V and other drug resistanceconferring mutations in interactions with nucleoside analog triphosphates.J Mol Biol, 1998,277(2) :237-247.
-
8Larder BA, Bloor S, Kemp SD, et al. A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance. Antimicrobial Agents Chemother, 1999,43(8): 1961-1967.
-
9Shirasaka T, Kavlick MF, Ueno T, et al. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Nat Acad Sci USA,1995,92(6) :2398-2402.
-
10Romano L, Venturi G, Bloor S, et al. Board nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.J Infect Dis,2002,185(7):898-904.
同被引文献28
-
1周婷,谢蓝.HIV非核苷类逆转录酶抑制剂研究进展[J].药学学报,2004,38(8):666-672. 被引量:17
-
2裴明军,桂向东,宋礼华.Cyanovirin-N:一种新型灭活HIV-1蛋白的研究进展[J].国外医学(预防.诊断.治疗用生物制品分册),2004,27(5):220-224. 被引量:4
-
3丁玉兰,赵树进,蒋琳兰,陈晓晖.HIV疫苗的研究进展[J].广东医学,2004,25(11):1342-1344. 被引量:1
-
4梁峰,李科,李国秀.HIV-1逆转录酶抑制剂的研究新进展[J].解放军药学学报,2004,20(6):450-453. 被引量:2
-
5Dealaney S,Zheng N,McQueen P.Emergency of drug2resistant HIV21 strains from patients on long term ddI therapy[C].12th World AIDS Conference.Geneva,1998,41:224.
-
6Hirsch MS,Brun2 Vezinet F,D'aquila RT,et al.Antiretroviral drug resistance testing in adults with HIV infection[J].JAMA,2000,283(18):2417-2426.
-
7Servais J,Plesseria JM,Lambert C,et al.Genotypic correlates of resistance to HIV-1 protease inhibitors onlongitudinal data:the role of secondary mutation[J].Antivir Ther,2001,6(4):239-248.
-
8Rodriguez 2 Rosado R,Briones C,Soriano V.Introduction of HIV drug resistance testing in clinical practice[J].AIDS,1999,13:1007-1014.
-
9HirschM S,Conway B,D'Aquila RT,et al.Antiretroviral drug resistance testing in adults with HIV infection;implication for clinicalmanagement.International AIDS society USA panel[J].JAMA,1998,279:1984-1991.
-
10Argante Bozzi,Fabrizia Brisdelli,Anna M. D’Alessandro,Gabriele D’Andrea,Anna R. Lizzi,Andrea C. Rinaldi,Arduino Oratore.Effects of AZT on cellular iron homeostasis[J]. BioMetals . 2004 (4)
引证文献2
-
1郭万申,胡清海,张旻,崔为国,李宏.河南省某地区HIV感染者治疗和耐药现况调查[J].中国艾滋病性病,2006,12(4):304-306. 被引量:7
-
2苗素平,格根通拉嘎,张立全,苗素生.艾滋病治疗药物研究进展[J].北方药学,2006,3(2):40-43.
二级引证文献7
-
1崔岩,张霞,钱兵,王玮,孟昭祥.中国抗AIDS药物费用现状分析[J].中国艾滋病性病,2009,15(6):557-559. 被引量:3
-
2孙冬,张梅光,李瑞玲,徐艳云,徐东红,孙锦山.自体血浆MB/光化学病毒灭活疗法对HIV/AIDS.TAA的疗效分析[J].河南大学学报(医学版),2010,29(2):120-122. 被引量:3
-
3毛霖,汪习成.抗HIV药物临床耐药研究进展[J].中国艾滋病性病,2011,17(1):92-95. 被引量:5
-
4佐合拉·吐尔地,廖玲洁,董永慧,邢辉,孙峰,阮玉华,马祥荣,开赛尔,地力努尔,邵一鸣.新疆部分艾滋病病人抗病毒治疗效果和耐药变异分析[J].中国艾滋病性病,2011,17(2):107-110. 被引量:13
-
5张云桂,周曾全,刑辉,廖玲洁,段松,劳云飞,李惠琴.云南省140例HIV/AIDS患者抗病毒治疗效果和耐药检测分析[J].卫生软科学,2012,26(1):38-41. 被引量:14
-
6于荣辉,绳宇,朱赛楠.艾滋病患者抗病毒治疗依从现状的调查分析[J].中华临床医师杂志(电子版),2012,6(11). 被引量:8
-
7KANG Lai-Yi.Current human immunodeficiency virus epidemic and its response in China[J].微生物与感染,2012,7(3):133-141.
-
1多种因素可引起HIV治疗相关的肝毒性[J].传染病网络动态,2007(2):9-9.
-
2崔婷,赵美香,武琴,胡靖.健康体检心电图18 636例分析[J].心脏杂志,2013,25(1):126-127. 被引量:3
-
3范志红.警惕无糖食品中的“隐性糖”[J].家庭医药(快乐养生),2010(9):12-13. 被引量:1
-
4孙玉,陈德喜.核苷类逆转录酶抑制剂线粒体毒性发病机制的研究进展[J].临床荟萃,2009,24(4):352-354. 被引量:3
-
5卢俊敏,马丽娜,赵中夫,杨柳絮,韩红莉,常蕴青.核苷类药物抗病毒治疗对HBV感染者血清IFN-γ和IL-2水平的影响及临床意义[J].长治医学院学报,2008,22(6):405-407. 被引量:2
-
6程志坚.HIV-1逆转录酶抑制剂的研究现状及展望[J].九江学院学报(自然科学版),2011,26(4):97-101.
-
7李雪莲.阿德福韦酯对慢性乙型肝炎患者外周血Th17细胞及相关细胞因子变化的影响[J].肝脏,2012,17(2):117-119.
-
8戴小波,唐文志,彭瑟,曾朱君,黄小燕,尹晓卓.耐核苷类药物的乙型肝炎病毒P区逆转录酶基因序列分析的研究[J].国际检验医学杂志,2013,34(9):1063-1064.
-
9韩燕星,李建农,傅连霞,蒋建东.检测HIV-1逆转录酶活性的ELISA方法的建立[J].中华微生物学和免疫学杂志,2004,24(9):748-750.
-
10WHO肯定抗逆转录疗法抗艾作用[J].中国医药技术与市场,2005,5(4):58-58.