摘要
HIV 1逆转录酶 (HIV 1reversetranscriptase ,HIV 1RT)是HIV 1复制所必需的酶 ,但是正常的细胞复制不需要它参与 ,因而 ,HIV 1RT成为抗艾滋病 (AIDS)药物设计的一个理想的靶点。目前 ,有效的抗HIV 1RT的药物根据它们的结构可以分为 :核苷类、非核苷类和核苷酸类逆转录酶抑制剂。本文综述了近几年HIV 1RT抑制剂的研究新进展。
出处
《解放军药学学报》
CAS
2004年第6期450-453,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
参考文献17
-
1Smith P F,Forrest A,Ballow C H,et al.Absolute bioavailability and disposition of (-) and (+) 2'-deoxy- 3'-oxa-4'-thiocytidine (dOTC) following single intravenous and oral doses of racemic dOTC in humans[J].Antimicrob Agents Chemother,2000,44(6):1609
-
2Richard N,Salomon H,Rando R,et al.Selection and characterization of human immunodeficiency virus type 1 variants resistant to the (+) and (-) enantiomers of 2'-deoxy-3'-oxa-4'-thio-5-fluorocytidine[J].Antimicrob Agents Chemother,2000,44(5):1127
-
3Uckun F M,Pendergrass S,Venkatachalam T K,et al.Stampidine is a potent inhibitor of Zidovudine and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations[J]
-
4Ranise A,Spallarossa A,Schenone S,et al.Design,synthesis,SAR,and molecular modeling studies of acylthiocarbamates:a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives
-
5Naesens L,Bischofberger N,Augustijns P,et al.Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice[J].Antimicrob Agents Chemother,1998,42(7):1568
-
6Gupta S P.Advances in QSAR studies of HIV-1 reverse transcriptase inhibitors[J].Prog Drug Res,2002,58:223
-
7Choo H,Chong Y,Choi Y,et al.Synthesis,anti-HIV activity,and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides[J].J Med Chem,2003,46(3):389
-
8Sorbera L A,del Fresno M,Lesson P A,et al.DPC-083[J].Drugs Fut,2002,27(4):331
-
9Artico M.Selected non-nucleoside reverse transcriptase inhibitors(NNRTIs):the DABOs family[J].Drugs Fut,2002,27(2):159
-
10Gaudio A C,Montanari C A.HEPT derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase:QSAR studies agree with the crystal structures[J].J Comput Aided Mol Des,2002,16(4):287
同被引文献36
-
1周婷,谢蓝.HIV非核苷类逆转录酶抑制剂研究进展[J].药学学报,2004,38(8):666-672. 被引量：17
-
2裴明军,桂向东,宋礼华.Cyanovirin-N:一种新型灭活HIV-1蛋白的研究进展[J].国外医学（预防．诊断．治疗用生物制品分册）,2004,27(5):220-224. 被引量：4
-
3丁玉兰,赵树进,蒋琳兰,陈晓晖.HIV疫苗的研究进展[J].广东医学,2004,25(11):1342-1344. 被引量：1
-
4姚勤伟,黄春,吴昊.HIV-1逆转录酶耐核苷类药物突变新进展[J].国外医学（流行病学．传染病学分册）,2004,31(6):343-345. 被引量：2
-
5张宏梁,肖宏.临床试验阶段的抗人免疫缺陷病毒化学药物研究进展[J].中国新药与临床杂志,2006,25(5):388-392. 被引量：3
-
6[1]White AJ.Mitoehondrial toxicity and HIV therapy.Sexually Transmitted Infections,2001,77:158-173.
-
7[2]张象麟,武志昂.药物临床信息参考.成都:四川科学技术出版社,2005.
-
8[4]Margolis DM,Mukherjee AL,Fletcher CV,et al.Theuse of betaD-2,6-diaminopurine dioxolane with or without mycophanolate mofetil in drug-resistant HIV infection.AIDS,2007,21(15):2025-2032.
-
9[5]Thompson MA,Kessler HA,Eron JJ Jr,,et al.Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients.AIDS,2005,19(15):1607-1615.
-
10[6]de Baar MP,de Rooii ER,Smolders KG,et al.Effects of apricitabine and other nueleoside reverse transcfiptase inhibitors on replication of mitochmdrial DNA in HepG2 cells.Antiviral Res,2007,76(1):68-74.
-
1赵春清,张媛玲.静脉输注紫杉醇渗漏1例护理[J].基层医学论坛,2009,13(6):186-186.
-
2程志坚.HIV-1逆转录酶抑制剂的研究现状及展望[J].九江学院学报（自然科学版）,2011,26(4):97-101.
-
3王晋.抗结核治疗合并HBV感染的结核病患者肝损害的发生及其临床治疗的探讨[J].现代诊断与治疗,2016,27(3):494-495. 被引量：2
-
4欧阳昕(综述),戴勇(综述).单核苷酸多态性与系统性红斑狼疮易感性研究进展[J].国际泌尿系统杂志,2010,30(2):245-248. 被引量：2
-
5王淼,李用国.核苷(酸)类似物治疗慢加急性肝衰竭研究进展[J].临床肝胆病杂志,2012,28(5):391-394. 被引量：1
-
6纪庆松.核苷类药物在乙肝治疗过程的相关问题[J].中国中医药咨讯,2010(17):266-266.
-
7刘文华,杨湛,应若素.核苷（酸）类似物停药后复发及长期用药的安全性[J].国际流行病学传染病学杂志,2015,42(3):205-207.
-
8张兴文.病毒性脑炎76例临床诊断与治疗分析[J].中国现代医生,2010,48(5):140-141. 被引量：1
-
91型糖尿病治疗找到新方法[J].糖尿病新世界,2004(4):62-62.
-
10郑志恒,樊金霞,刘杰.影响化疗药物作用效果的几点注意事项[J].中国医药指南,2014,12(35):389-389. 被引量：1
