新生儿缺氧缺血性脑病相关生物学研究进展
被引量：1
摘要
新生儿缺氧血性脑病(HIE)不仅可引起围产期新生儿死亡，而且是新生儿期以后造成伤残儿童的主要原因之一。其发病机制复杂，随着现代免疫学和分子生物学的迅速发展，近几年大量研究证明，脑缺氧缺血后可激活一系列分子反应，一部分可进一步介导脑损伤，同时也有一部分对脑组织起着保护性作用。相关生物学研究，对HIE预后以及干预治疗均有十分重要意义。复习有关文献综述如下。
出处
《新生儿科杂志》
2004年第6期283-285,共3页
The Journal of Neonatology
参考文献16
-
1Bertrand N, Siren AL, Tworek D, et al. Differential expression of HSC73 and HSP72mRNA and proteins between young and adult gerbils after transient cerebral ischemia: relation to neuronal vuluerability [J]. J Cereb Blood Flow Metab, 2000,20(7) : 1056 - 65.
-
2Hata R, Maeda K, Hermann D, et al. Evolution of brain infarction after transient focal cerebral ischemia in mice(J), J Cereb Blood Flow Metab,2000, 20(6):937-46.
-
3Lee SH, Kim M, Yoon BW, et al. Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice(J). Stroke, 2001, 32(12) :2905- 12.
-
4Ota A, Ikeda T, Xia XY, et al. Hypoxic-ischemic tolerance induced by hyperthermic pretreatraent in newborn rats[ J ]. J Soc Gynecol Investig, 2000, 7(2) : 102 - 105.
-
5Jayakumar J, Suzuki K, Satmnut IA, et al. Heat shock protein 70 gene transfection protects mitochondrial and ventricutar function against ischemia - teperfusion injury ( J ). Circulation, 2001, 104( 12 Suppll) : 1303 - 07.
-
6Cabai VL, Yaglom JA, Volloch V, et al. HSP72- mediated suppression of C - Jun N - terminal Kinase is implicated in development of tolenance to caspase- independent cell death(J). Mol cell Bid, 2000,20(18):6826-36.
-
7Mddmm KK, Meldmm DR. Sezea SF, et al. Heat shock prevents simulated ischemin - induced apoptosis in renal tubular cells via a PKC - dependent meehanimn [J]. AM J Physiol Regul Integr Camp Physiol, 2001, 281( 1 ) : 359 - 64.
-
8Uchinami H, Yamamoto Y, Kume M, et al. Effect of heat stock preconditioning on NF - KappaB/I - KappaB Pathway Luring I/R injury of the rat liver[J]. Am J Physiol Gastrointest Liver Physiol, 2002, 282(6) : G962 - 71.
-
9Lu A, Ran RQ, dark J, et al. 17 - beta- esfradinl induces heat stock proteins in brain arteries and potentiates ischemic heat stock protein induction in glia and neurons(J). J Cereb Blood Flow Metab, 2002, 22(2): 183- 195.
-
10Hoehu B, Ringer TM, Xu L, et al. Overexpression of HSP70 after induction of experimental stroke protects neurons from ischemic damage(J). J Cereb Blood Flow Metab, 2001, 21(11): 1303-09.
同被引文献6
-
1Marti HH.Erythropoietin and the hypoxic brain.J Exp Biol,2004,207:3233-3242.
-
2Boogaerts M.Pleiotropic effects of erythropoietin in neuronal and vascular systems.Curr Med Res Opin,2006,4:15-22.
-
3Demers EJ,Mcpherson RJ,Juul SE.Erythropoietin protects dopaminergic neurons and improves neurobehavioral outcomes in juvenile rats after neonatal hypoxia ischemia.Pediatr Res,2005,58:297-301.
-
4Grimm C,Wenzel A,Acar N,et a1,Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration.Adv Exp Med Biol,2006,588:119-131.
-
5Prior H,Schwegler H,Marashi V,et al,Exploration,emotionality,and hippocampal mossy fibers in nonaggressive AB/Gat and congenic highly aggressive mice.Hippocampus,2004,14:135-140.
-
6Ten VS,Wu EX,Tang H,et al,Late measures of brain injury after neonatal hypoxia-ischemia in mice.Stroke,2004,35:2183-2188.
二级引证文献4
-
1张永红,谢利娟,朱建幸.促红细胞生成素对早产儿脑损伤的保护作用[J].中国新生儿科杂志,2007,22(6):375-377. 被引量：2
-
2严争,林敦彬,康强,刘凡,赵兰玉,危夷,王健,郑丽芬,李慧贞,成辉,潘香凝,黄勉,谢玲.新生儿脐血促红细胞生成素和内皮素测定的临床意义[J].实用儿科临床杂志,2009,24(14):1127-1128.
-
3龙小雅,崔红,韩伟娟.促红细胞生成素的神经保护作用[J].中国新生儿科杂志,2010,25(1):53-56. 被引量：3
-
4蔡岳鞠,宋燕燕,刘青,周卓妍,李坚,黄志坚.促红细胞生成素对3日龄脑白质损伤新生大鼠髓鞘碱性蛋白和神经行为学的影响[J].中国新生儿科杂志,2013,28(4):264-268. 被引量：8
-
1陈海平.兴奋性氨基酸与新生儿缺氧缺血性脑病[J].中国微循环,2006,10(3):223-225.
-
2刘文华,韩文玲,章咏华,吴兆芳,陈嘉,姜凤萍.高压氧早期干预对围产期缺氧缺血性脑病新生儿预后的影响[J].中国厂矿医学,2009,22(4):462-462. 被引量：2
-
3夏正坤,陈荣华.母乳中肿瘤坏死因子-α对新生儿保护性作用的探讨[J].中国优生优育（1990-2002上半年）,1995,6(2):49-51.
-
4王秋云,张红.高压氧治疗新生儿缺氧缺血性脑病212例疗效观察及护理[J].牡丹江医学院学报,2006,27(1):76-78. 被引量：4
-
5宋子皊,叶巍岭.脑活素治疗新生儿缺氧缺血性脑病30例报告[J].南通医学院学报,1995,16(4):612-612.
-
6冯国祝,彭珊璐,詹淑贞.新生儿缺氧缺血性脑病血镁对照研究[J].中国优生与遗传杂志,2004,12(S1).
-
7黄书峰,张明.新生儿缺氧血性脑病的CT表现[J].医用放射技术杂志,2002(2):86-86.
-
8潘新年.新生儿缺氧血性脑病50例临床分析[J].广西医学,1996,18(4):405-406.
-
9潘未未.纳洛酮治疗新生儿HIE20例疗效观察[J].中国优生与遗传杂志,2000,8(4):61-61. 被引量：2
-
10林丽芳.新生儿窒息新法复苏的体会[J].福建医药杂志,2003,25(3):228-228.
