枸橼酸,琥珀酸和抗瘤酮AS_(2-5)与金属离子配位能力的研究

METAL CHELATING ABILITY STUDIES OF CITRIC ACID SUCCINIC ACID AND PHENYLGLUTAMIDE AS_(2-5)

探讨了枸橼酸、琥珀酸、抗瘤酮AS_(2-5)与微量元素的螯合能力,并用pH电势法测定其在生理条件下与Ca(Ⅱ),Mg(Ⅱ),Mn(Ⅱ),Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ),Fe(Ⅲ),Pt(Ⅳ)等离子形成螯合物的螯合稳定常数。结果:AS_(2-5)仅与少数离子螯合,而枸橼酸、琥珀酸可与多种金属离子螯合,与Pt(Ⅳ)有较强的螯合能力。

The chelating abilities of metal ions with Citric acid(CIA), succinic acid(SNA)and phenylglutamide(AS_(2-5))were studied.There are many carboxy groups in the above compounds.The Oxygen atom of the carboxy group has strong chelating ability.So the CIA,SNA and AS_(2-5)as multidendate ligand have definite chelating ability. In this article,The chelating actions of CIA,SNA and AS_(2-5)with Ca(Ⅱ),Mg(Ⅱ),Mn(Ⅱ),Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ), Cd(Ⅱ),Fe(Ⅲ),Pt(Ⅳ)ions were determined by pH potentiometry at biological condition.The protonation constants and metal chelate stability constants were determined by pH potentiometry.The data were treated by the PC-1500 computer with the programs of formation function methods. The results showed that CIA,SNA AS_(2-5)have different chelating ability. AS_(2-5)is only able to chelate with Zn(Ⅱ)and Fe(Ⅲ).But CIA and SNA have higher chelating ability with Pt(Ⅳ)besides that with Ni(Ⅱ)、 Cd(Ⅱ)、Cu(Ⅱ)and Mg(Ⅱ).